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Synthesis of hyaluronidase is a specific enzyme that breaks down the hyaluronic acid of norvasc substance, which contributes to the penetration of bacteria into the human body and their spread in it. The release of substances that inhibit (inhibit) the phagocytic activity of macrophage leukocytes - this makes it possible for intracellular parasitism of bacteria inside the cells of the immune system and a long course of the infectious process in the human body. The ability to allergize the human body due to the release of protein substances, metabolic products of bacterial cells.

The release of a powerful endotoxin during the death and destruction of bacterial cells - it causes severe intoxication of the human body and metabolic disorders in it.

The formation of special L- and S-forms of bacteria that are resistant to antibiotics and human immunity due to a change in their genetic structure.

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These features (aggression factors) of Brucella determine the course of the disease and the mechanism of its development (pathogenesis).

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Systemic lesions are diverse and affect almost all organs. musculoskeletalspruce apparatus: septic monoarthritis, asymmetric polyarthritis of the knee, hip, shoulder sacroiliac and sternoclavicular joints, osteomyelitis of the spine, myalgia. Heart: endocarditis, myocarditis, pericarditis, aortic root abscess, thrombophlebitis, and endocarditis can develop on previously unchanged valves. Respiratory system: bronchitis and pneumonia. Digestive system: anicteric hepatitis, anorexia and weight loss. Genitourinary system: epididymitis, orchitis, prostatitis, tubo-ovarian abscess, salpingitis, cervicitis, acute pyelonephritis.


amlodipine develops, as a rule, gradually and has no specific symptoms. But patients usually present four main complaints:


  • The incubation period for brucellosis in humans is 1-2 weeks.
  • There are practically no organs and systems where brucella would not visit.
  • The next stage of the spread of the infection is associated with its entry into the bloodstream, which contributes to further progress throughout norvasc pills.
  • Macrophage cells rise to fight the pathogen, but they only capture the infection and bring it to the lymph nodes. On the way, the bacteria actively multiply, and getting into the lymph flow, they lead to local inflammation of the lymph nodes.

As already mentioned, the infection enters through the wound surface during contact of a person with infected objects. Brucella enters the body both through damaged skin and through mucous membranes.

Boiling in water kills them instantly, they are also sensitive to antiseptic solutions (hydrogen peroxide, alcohol, furatsilin, bleach, chloramine).